The Office of Environmental Health Hazard Assessment (OEHHA) is adding 4-methylimidazole (CAS No. 822-36-6) to the list of chemicals known to the state to cause cancer for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65). The listing of 4-methylimidazole is effective January 7, 2011.
California OEHHA added 4-methylimidazole (4-MEI), a byproduct of ammonia-process caramel color, to the Proposition 65 list of chemicals known to cause cancer, effective January 7, 2011.
4-Methylimidazole is possibly carcinogenic to humans (Group 2B).
The International Agency for Research on Cancer (IARC) classifies 4-methylimidazole as possibly carcinogenic to humans (Group 2B).
Twelve brands of sodas and soft drinks from five manufacturers - including Coca-Cola, Pepsi, and Goya - were tested. Two products, Pepsi One and Malta Goya, exceeded 29 micrograms per can or bottle.
Consumer Reports lab-tested 12 soda/soft-drink brands and found 4-MEI in all products listing caramel color; Pepsi One and Malta Goya exceeded the 29-microgram California Prop 65 threshold per serving, while Coca-Cola products had the lowest levels.